Aromatase Inhibitors: The Precursor To Treat Cancer


Aromatase Inhibitors lower the estrogen levels by inhibiting the enzyme aromatase to convert into estrogen. Estrogens occur in the body by converting precursor molecule into estrogen, promoting the growth of breast epithelial cells, leading to gynecomastia. The estrogen receptors are bound and activated. They cannot distinguish the normal cells with that of cancerous cells, and hence for this, it is often considered the first line choice of drug for tumors in the breast. It has the reducing effects on the risks associated with gynaecomastia and enhances the recovery of natural testosterone production after a cycle. The American Science Labs conducts experiments on aromatase inhibitors. The elevated estrogen levels pose a serious threat to women, and this drug is used to avoid bloating related to anabolic steroids.

If a bodybuilder uses androgenic steroids, and upon regular use, high estrogen levels cause gynecomastia that inhibits natural testosterone production. High estrogen also has carcinogenic metabolic remnants and shall pose liver disorders. A comparative analysis is essential to understand the efficacy of aromatase inhibitors. Aromatase inhibitors are often prescribed as an initial drug of choice against cancer. When treated at an early stage, it has a positive outcome on breast cancers. Tamoxifen is a late choice for the treatment which requires 5years completely.It prevents the rebounding of cancer for life. Look into to find out how can similar comparative analysis be conducted and obtained results.

The aromatase Inhibitors are proved to cause heart problems, bone marrow loss, depletion of bones to become brittle. Myalgia and Arthralgia are common side effects of aromatase inhibitors. In rare cases, it can even lead to carpal tunnel syndrome. Women are reported to have joint pain and muscle spasm after consuming these inhibitors. They enable to maintain the non-mineral density of bones too.

Elevated estrogen levels whether deficient or higher, will cause detrimental effects on cardiovascular health that eventually lead to atherosclerosis. Hence, maintaining an optimal level of estrogen is necessary for the heart. Dosing of Aromatase inhibitors is another factor to be considered during the therapy. Irregular schedules of the drug lead to variable swings in the blood estrogen levels. This makes aromatization occur at fluctuated levels leading to unstable estrogen. Hence the uptake would be changed, affecting the release, and turbulence of flow. So, a steady state of estrogen level in the blood is to be followed throughout the therapy.

Another area of specialization which failed to produce appreciable results is the effects of Aromatise Inhibitors on lipids. Fortunately, some conclusions that give satisfactory results were made to draw attention towards it. Drugs like letrozole, anastrozole and exemestane are taken into the study, and it was found that the worst performer is letrozole, while the lease harmful one is the exemestane, with findings from some female species. The effect of AI on Blood brain barrier is also studied in animal models, the neurosteroid balance was found to maintain by exemestane, with rapid clearance producing the effect. Thus, various findings and research conclude that this can be a reliable drug for many of the diseases.